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Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice

  1. Author:
    Wakitani, S.
    Hondo, E.
    Shimokawa, T.
    Kusakabe, K.
    Okada, T.
    Nakamuta, N.
    Stewart, C. L.
    Kiso, Y.

  2. Author Address

    Wakitani, Shoichi, Hondo, Elichi, Kiso, Yasuo] Yamaguchi Univ, Fac Agr, Dept Vet Anat, Yamaguchi 7538511, Japan. [Shimokawa, Tetsuya] Ehime Univ, Sch Med, Div Anat & Embryol, Dept Integrated Biol Sci, To On City, Ehime 7910295, Japan. [Kusakabe, Ken] Osaka Med Coll, Dept Anat & Biol, Takatsuki, Osaka 5698686, Japan. [Okada, Toshiya] Univ Osaka Prefecture, Fac Vet Sci, Dept Vet Embryol, Lab Anim Sci, Sakai, Osaka 5998531, Japan. [Nakamuta, Nobuaki] Kyushu Dent Coll, Dept Oral Anat 1, Kokura 8538580, Japan. [Stewart, Colin L.] NCI Frederick, Canc & Dev Biol Lab, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Immunobiology
    1. 213
    2. 2
    3. Pages: 143-150
  4. Type of Article: Article
  1. Abstract:

    Lectin histochemistry was performed on mouse uteri to determine what effects leukemia inhibitory factor (LIF) has on carbohydrate epitope expressions at the time of implantation. Twenty-two biotinylated lectins were used in this study. Following injection of LIF, specific binding to the apical surface of the uterine glandular epithelium (GE) was recognized by six lectins. Particularly, binding of the lectin from Griffonia (Bandeiraea) simplicifolia was specific to the glandular epithelium close to the luminal epithelium. Succinylated wheat germ agglutinin (WGA), which has specificity for oligosaccharides recognized by WGA without sialic acid residues, showed weaker binding to the uterine luminal epithelium (LE) and the stroma than WGA, suggesting that terminal residues of glyco-conjugates on these tissues may be modified by sialic acids. Lectin binding to the glandular and luminal epithelium was not influenced by LIF. However, three lectins including a lectin from Dolichos biflorus showed specificity for stromal vessels 6h after LIF injection. Since the lectin from D. biflorus binds to neo-vascular vessels, LIF may play a role in regulating maternal angiogenesis directly and/or indirectly during implantation. (c) 2007 Elsevier GmbH. All rights reserved.

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External Sources

  1. PMID: 18241698

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