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Tumor immunobiological differences in prostate cancer between African-American and European-American men

  1. Author:
    Wallace, T. A.
    Prueitt, R. L.
    Yi, M.
    Howe, T. M.
    Gillespie, J. W.
    Yfantis, H. G.
    Stephens, R. M.
    Caporaso, N. E.
    Loffredo, C. A.
    Ambs, S.
  2. Author Address

    Wallace, Tiffany A.; Prueitt, Robyn L.; Howe, Tiffany M.; Ambs, Stefan] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. [Gillespie, John W.] NCI, NIH, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Yi, Ming, Stephens, Robert M.] Sci Applicat Int Corp Frederick Inc, Natl Canc Inst, Adv Biomed Comp Ctr, Frederick, MD USA. [Yfantis, Harris G.] Baltimore Vet Affairs Met Ctr, Pathol & Lab Med, Baltimore, MD USA. [Caporaso, Neil E.] NCI, NIH, Genet Epidemiol Branch, Div Canc Epidemol & Genet, Rockville, MD USA. [Loffredo, Christopher A.] Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Canc Genet & Epidemiol Program, Washington, DC 20007 USA.
    1. Year: 2008
  1. Journal: Cancer Research
    1. 68
    2. 3
    3. Pages: 927-936
  2. Type of Article: Article
  1. Abstract:

    The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared with European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical variables. We also evaluated 18 nontumor prostate tissues from seven African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate of <= 5% to be differently expressed between African-American and European-American patients. Using a disease association analysis, we identified a common relationship of these transcripts with autoimmunity and inflammation. These findings were corroborated on the pathway level with numerous differently expressed genes clustering in immune response, stress response, cytokine signaling, and chemotaxis pathways. Several known metastasis-promoting genes, including autocrine mobility factor receptor, chemokine (C-X-C motif) receptor 4, and matrix metalloproteinase 9, were more highly expressed in tumors from African-Americans than European-Americans. Furthermore, a two-gene tumor signature that accurately differentiated between African-American and European-American patients was identified. This finding was confirmed in a blinded analysis of a second sample set. In conclusion, the gene expression profiles of prostate tumors indicate prominent differences in tumor immunobiology between African-American and European-American men. The profiles portray the existence of a distinct tumor microenvironment in these two patient groups.

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External Sources

  1. PMID: 18245496

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