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P53-Independent Inhibition of Nitric Oxide Generation By Cancer Preventive Interventions in Ex Vivo Mouse Peritoneal Macrophages

  1. Author:
    Mei, J. J. M.
    Hursting, S. D.
    Perkins, S. N.
    Phang, J. M.
    1. Year: 1998
  2. Journal: Cancer Letters
    1. 129
    2. 2
    3. Pages: 191-197
  4. Type of Article: Article
  1. Abstract:

    We have previously reported that dietary interventions with purported anti-inflammatory activity delay spontaneous tumorigenesis in p53-deficient (p53(-/-)) mice. In the present study, 4 weeks of calorie restriction or the dietary administration of chemopreventive steroids dehydroepiandrosterone and 16 alpha-fluoro-5-androsten-17-one significantly reduced the inducible generation of nitric oxide (NO) in ex vivo peritoneal macrophages from male p53 wild-type and p53(-/-) mice relative to the respective ad libitum-fed controls; expression of inducible nitric oxide synthase II (NOS2) protein was also markedly decreased compared with respective controls. These findings suggest that the p53-independent suppression of inducible NO production observed in this study may contribute to the anti-cancer effects of these preventive interventions in p531(-/-) mice. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved. [References: 21]

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