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Chemerin reveals its chimeric nature

  1. Author:
    Yoshimura, T.
    Oppenheim, J. J.

  2. Author Address

    Yoshimura, Teizo, Oppenheim, Joost J.] NCI, Ctr Canc Res, Canc & Inflammat Program, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Journal of Experimental Medicine
    1. 205
    2. 10
    3. Pages: 2187-2190
  4. Type of Article: Editorial Material
  1. Abstract:

    Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

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External Sources

  1. PMID: 18809717

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