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The Cc Chemokine 6ckine Binds the Cxc Chemokine Receptor Cxcr3

  1. Author:
    Soto, H.
    Wang, W.
    Strieter, R. M.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Hedrick, J.
    Zlotnik, A.
    1. Year: 1998
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 95
    2. 14
    3. Pages: 8205-8210
  4. Type of Article: Article
  1. Abstract:

    We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells, In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10(-/-) mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent. [References: 39]

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