Skip NavigationSkip to Content
Return Return to Search Results

APOBEC3B Deletion and Risk of HIV-1 Acquisition

  1. Author:
    An, P.
    Johnson, R.
    Phair, J.
    Kirk, G. D.
    Yu, X. F.
    Donfield, S.
    Buchbinder, S.
    Goedert, J. J.
    Winkler, C. A.

  2. Author Address

    Winkler, Cheryl A.] NCI, Lab Genom Div, SAIC Frederick, FCRDC, Frederick, MD 21702 USA. [Kirk, Gregory D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Yu, Xiao-Fang] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Goedert, James J.] NCI, Infect & Immunoepidemiol Branch, Bethesda, MD 20892 USA. [Phair, John] Northwestern Univ, Chicago, IL 60611 USA. [Donfield, Sharyne] Rho, Chapel Hill, NC USA. [Buchbinder, Susan] San Francisco Dept Publ Hlth, San Francisco, CA USA.
    1. Year: 2009
  2. Journal: Journal of Infectious Diseases
    1. 200
    2. 7
    3. Pages: 1054-1058
  4. Type of Article: Proceedings Paper
  1. Abstract:

    The human APOBEC3 family of cytidine deaminases provides intrinsic immunity to retroviral infection. A naturally occurring 29.5-kb deletion removes the entire APOBEC3B gene. We examined the impact of the APOBEC3B gene deletion in >4000 individuals from 5 human immunodeficiency virus type 1 (HIV-1) natural history cohorts. The hemizygous genotype had no effect on either acquisition of HIV-1 infection or progression to AIDS. However, the homozygous deletion was significantly associated with unfavorable outcomes for HIV-1 acquisition (odds ratio, 7.37, P = .024), progression to AIDS (relative hazard, 4.01, P = .03) and viral set point (P = .04). These findings suggest that the loss of APOPBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1086/605644
  3. PMID: 19698078

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel