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Hepatitis C Viral Kinetics During Treatment With Peg IFN-alpha-2b in HIV/HCV Coinfected Patients as a Function of Baseline CD4(+) T-Cell Counts

  1. Author:
    Avidan, N. U.
    Goldstein, D.
    Rozenberg, L.
    McLaughlin, M.
    Ferenci, P.
    Masur, H.
    Buti, M.
    Fauci, A. S.
    Polis, M. A.
    Kottilil, S.

  2. Author Address

    Avidan, Neumann U.; Rozenberg, Lynn] Bar Ilan Univ, Ramat Gan, Israel. [Kottilil, Shyam] NIAID, Immunopathogenesis Sect, NIH, LIR,DHHS, Bethesda, MD 20892 USA. [Avidan, Neumann U.] NIDDK, LBM, NIH, DHHS, Bethesda, MD USA. [Goldstein, Deborah] Sci Applicat Int Corp Frederick, Frederick, MD USA. [Ferenci, Peter] Univ Hosp Vienna, Vienna, Austria. [Masur, Henry] NIH, CCMD, CC, DHHS, Bethesda, MD 20892 USA. [Buti, Maria] Univ Valle Hebron, Gen Hosp, Barcelona, Spain. [Buti, Maria] Ciber Ehd Intituto Carlos III, Barcelona, Spain.
    1. Year: 2009
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 52
    2. 4
    3. Pages: 452-458
  4. Type of Article: Article
  5. ISSN: 1525-4135
  1. Abstract:

    Background: HIV/hepatitis C virus (HCV) coinfected patients are known to have lower sustained viral response (SVR) rates than HCV monoinfected patients. However, the role of CD4(+) T-cell counts on viral kinetics and outcome is not fully understood. Methods: HCV RNA kinetics (bDNA v3, lower limit of detection [LD] = 615 IU/mL) was analyzed in 32 HIV/HCV coinfected persons treated with Pegylated-interferon-alpha 2b (1.5 mu g/kg weekly) and ribavirin (1-1.2 g daily) for 48 weeks and compared with results obtained from 12 HCV monoinfected patients treated with the same regimen. Results: Baseline CD4(+) T-cell counts >= 450 cells/mm(3) were significantly (P < 0.002) associated with SVR in coinfected genotype I patients. First phase decline was significantly lower among patients with low as compared with high CD4 counts (P < 0.03) and among coinfected compared with monoinfected patients (P < 0.002). Second phase decline slope showed a similar trend for coinfected patients. Conclusions: Low baseline CD4(+) T-cell count is associated with slower HCV viral kinetics and worse response to treatment among HIV coinfected patients, suggesting HCV treatment response depends on immune status. HCV genotype I coinfected patients have slower first phase viral kinetics than HCV monoinfected patients. First phase viral decline (>1.0 log) and second phase viral decline slope (>0.3 log/wk) are excellent predictors of SVR for coinfected patients.

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External Sources

  1. PMID: 19797971

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