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Noninvasive Monitoring of a Murine Model of Metastatic Pheochromocytoma: A Comparison of Contrast-Enhanced MicroCT and Nonenhanced MRI

  1. Author:
    Martiniova, L.
    Kotys, M. S.
    Thomasson, D.
    Schimel, D.
    Lai, E. W.
    Bernardo, M.
    Merino, M. J.
    Powers, J. F.
    Ruzicka, J.
    Kvetnansky, R.
    Choyke, P. L.
    Pacak, K.

  2. Author Address

    Martiniova, Lucia, Lai, Edwin W.; Pacak, Karel] NICHHD, Reprod & Adult Endocrinol Program, Bethesda, MD 20892 USA. [Kotys, Melanie S.] NHLBI, Bethesda, MD 20892 USA. [Thomasson, David] NIH, Warren Grant Magnuson Clin Ctr, Lab Diagnost Radiol, Bethesda, MD 20892 USA. [Schimel, Daniel] Natl Inst Neurol Disorders & Stroke, Mouse Imaging Facil, Charles River Labs, Bethesda, MD USA. [Bernardo, Marcelino, Choyke, Peter L.] NCI, Mol Imaging Program, Bethesda, MD 20892 USA. [Bernardo, Marcelino] NCI Frederick, SAIC Frederick, Lab Anim Sci Program, Frederick, MD USA. [Merino, Maria J.] NCI, Pathol Lab, Frederick, MD 21701 USA. [Powers, James F.] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA. [Powers, James F.] Tufts Univ New England Med Ctr, Boston, MA 02111 USA. [Ruzicka, Jan] Comenius Univ, Dept Nucl Sub Nucl Phys, Bratislava, Slovakia. [Martiniova, Lucia, Kvetnansky, Richard] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
    1. Year: 2009
  2. Journal: Journal of Magnetic Resonance Imaging
    1. 29
    2. 3
    3. Pages: 685-691
  4. Type of Article: Article
  1. Abstract:

    Purpose: To compare contrast-enhanced micro-computed tomography (microCT and nonenhanced respiratory-triggered magnetic resonance imaging (MRI) in an animal model of metastatic pheochromocytoma. Animal models are becoming important in the study of cancer treatment and imaging is useful in minimizing the number of animals needed and reducing costs associated with autopsies. However, the choice of imaging modality is still evolving. Materials and Methods: Adult female nude mice were injected by tail vein with a mouse pheochromocytoma (MPC) cell line (MPC 4/30PRR) to create a metastatic model. After optimizing imaging techniques, eight mice were imaged with both respiratory triggered MRI and microCT and the findings were verified histologically. Results: MicroCT and MRI were approximately equal in their ability to detect hepatic metastases at a size threshold of 350 mu m. In the lungs, MRI was more sensitive than microCT, detecting lesions 0.6 mm in diameter versus I mm for microCT. Additionally, MRI was more sensitive for lesions in the kidneys, bone, ovaries, and adrenal glands. MRI demonstrated a higher contrast-to-noise ratio (CNR) than microCT. Conclusion: In addition to the advantage of not exposing the animal to ionizing radiation, MRI provided a more complete assessment of the extent of metastases in this model compared to microCT.

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External Sources

  1. PMID: 19243052

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