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Efficacies of Zinc-Finger-Active Drugs Against Giardia Lamblia

  1. Author:
    Nash, T.
    Rice, W. G.
    1. Year: 1998
  2. Journal: Antimicrobial Agents and Chemotherapy
    1. 42
    2. 6
    3. Pages: 1488-1492
  4. Type of Article: Article
  1. Abstract:

    Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 mu M or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 mu M. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens. [References: 31]

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