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Syphilis co-infection does not affect HIV disease progression

  1. Author:
    Weintrob, A. C.
    Gu, W.
    Qin, J.
    Robertson, J.
    Ganeson, A.
    Crum-Cianflone, N. F.
    Landrum, M. L.
    Wortmann, G. W.
    Foliman, D.
    Agan, B. K.

  2. Author Address

    [Weintrob, A. C.; Ganeson, A.; Crum-Cianflone, N. F.; Landrum, M. L.; Agan, B. K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA. [Weintrob, A. C.; Wortmann, G. W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Gu, W.] SAIC Frederick, Biostat Res Branch, Frederick, MD USA. [Qin, J.; Foliman, D.] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Robertson, J.; Landrum, M. L.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Crum-Cianflone, N. F.] Naval Med Ctr San Diego, San Diego, CA USA. [Ganeson, A.] Natl Naval Med Ctr, Bethesda, MD USA.;Weintrob, AC, 6900 Georgia Ave NW,Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA.;Amy.Weintrob@amedd.army.mil
    1. Year: 2010
    2. Date: Jan
  2. Journal: International Journal of Std & Aids
    1. 21
    2. 1
    3. Pages: 57-59
  4. Type of Article: Article
  5. ISSN: 0956-4624
  1. Abstract:

    HIV and syphilis are often seen as co-infections since they share a common mode of transmission. During episodes of syphilis, CD4 counts transiently decrease and HIV viral loads increase; however, the effect of syphilis co-infection on HIV disease progression (time to AIDS or death) is unclear. We analysed prospectively collected information on 2239 persons with estimated dates of HIV seroconversion (205 [9.2%] with confirmed syphilis and 66 [2.9%] with probable syphilis) in order to determine the effect of syphilis co-infection on HIV disease progression. In multivariate models censored at highly active antiretroviral therapy (HAART) initiation or last visit, adjusting for CD4 count, age, race, gender, and hepatitis B and C status, syphilis (confirmed + probable) was not associated with increased hazard of AIDS or death (hazard ratio 0.99, 95% CI 0.73-1.33). Treating HAART as a time-varying covariate or limiting the analysis to only confirmed syphilis cases did not significantly alter the results. Despite transient changes in CD4 counts and viral loads, syphilis does not appear to affect HIV disease progression.

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External Sources

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  2. DOI: 10.1258/ijsa.2009.009164
  3. View record in Web of Science®
  4. WOS: 000274078400012

Library Notes

  1. Fiscal Year: FY2009-2010
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