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CD8+Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells

  1. Author:
    Klatt, N. R.
    Shudo, E.
    Ortiz, A. M.
    Engram, J. C.
    Paiardini, M.
    Lawson, B.
    Miller, M. D.
    Else, J.
    Pandrea, I.
    Estes, J. D.
    Apetrei, C.
    Schmitz, J. E.
    Ribeiro, R. M.
    Perelson, A. S.
    Silvestri, G.

  2. Author Address

    [Klatt, Nichole R.; Ortiz, Alex M.; Engram, Jessica C.; Paiardini, Mirko; Silvestri, Guido] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Klatt, Nichole R.; Lawson, Benton; Else, James; Silvestri, Guido] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [Shudo, Emi; Ribeiro, Ruy M.; Perelson, Alan S.] Los Alamos Natl Lab, Los Alamos, NM USA. [Miller, Michael D.] Gilead Sci Inc, Foster City, CA 94404 USA. [Pandrea, Ivona; Apetrei, Cristian] Tulane Univ, Tulane Natl Primate Res Ctr, New Orleans, LA 70118 USA. [Pandrea, Ivona; Apetrei, Cristian] Tulane Univ, Tulane Hlth Sci Ctr, New Orleans, LA 70118 USA. [Estes, Jacob D.] Sci Applicat Int Corp Frederick Inc, Natl Canc Inst, AIDS & Canc Virus Program, Frederick, MD USA. [Schmitz, Joern E.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.;Klatt, NR, Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.;gsilvest@mail.med.upenn.edu
    1. Year: 2010
    2. Date: Jan
  2. Journal: Plos Pathogens
    1. 6
    2. 1
    3. Pages: 11
  4. Type of Article: Article
  5. Article Number: e1000747
  6. ISSN: 1553-7366
  1. Abstract:

    While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV infections, the mechanisms underlying this antiviral effect remain poorly understood. In this study, we assessed the in vivo effect of CD8+ lymphocyte depletion on the lifespan of productively infected cells during chronic SIVmac239 infection of rhesus macaques. We treated two groups of animals that were either CD8+ lymphocyte-depleted or controls with antiretroviral therapy, and used mathematical modeling to assess the lifespan of infected cells either in the presence or absence of CD8+ lymphocytes. We found that, in both early (day 57 post-SIV) and late (day 177 post-SIV) chronic SIV infection, depletion of CD8+ lymphocytes did not result in a measurable increase in the lifespan of either short-or long-lived productively infected cells in vivo. This result indicates that the presence of CD8+ lymphocytes does not result in a noticeably shorter lifespan of productively SIV-infected cells, and thus that direct cell killing is unlikely to be the main mechanism underlying the antiviral effect of CD8+ T cells in SIV-infected macaques with high virus replication.

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External Sources

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  2. DOI: 10.1371/journal.ppat.1000747
  3. View record in Web of Science®
  4. WOS: 000274227100036

Library Notes

  1. Fiscal Year: FY2009-2010
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