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Cycling of gut mucosal CD4+T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels

  1. Author:
    Ciccone, E. J.
    Read, S. W.
    Mannon, P. J.
    Yao, M. D.
    Hodge, J. N.
    Dewar, R.
    Chairez, C. L.
    Proschan, M. A.
    Kovacs, J. A.
    Sereti, I.

  2. Author Address

    [Ciccone, E. J.; Hodge, J. N.; Chairez, C. L.; Sereti, I.] NIAID, Immunoregulat Lab, Bethesda, MD 20892 USA. [Read, S. W.] NIAID, Div Aids, Bethesda, MD 20892 USA. [Mannon, P. J.] Univ Alabama, Div Gastroenterol & Hepatol, Birmingham, AL USA. [Yao, M. D.] NIAID, Host Def Lab, Bethesda, MD 20892 USA. [Dewar, R.] SAIC Frederick Inc, Frederick, MD USA. [Proschan, M. A.] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Kovacs, J. A.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.;Sereti, I, NIAID, Immunoregulat Lab, Bldg 10, Bethesda, MD 20892 USA.;isereti@niaid.nih.gov
    1. Year: 2010
    2. Date: Mar
  2. Journal: Mucosal Immunology
    1. 3
    2. 2
    3. Pages: 172-181
  4. Type of Article: Article
  5. ISSN: 1933-0219
  1. Abstract:

    The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samples were collected from viremic, untreated, HIV-infected participants, patients treated with prolonged ART (>5 years), and uninfected controls and analyzed by flow cytometry. In the gut, the proportion of cycling T cells decreased and the number of CD4+ T cells normalized in treated patients in parallel with beta 7 expression on CD4+ T cells in blood. Cycling of gut T cells in viremic patients was associated with increased plasma LPS levels, but not colonic HIV-RNA. These data suggest that gut T-cell activation and microbial translocation may be interconnected whereas prolonged ART may decrease activation and restore gut CD4+ T cells.

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External Sources

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  2. DOI: 10.1038/mi.2009.129
  3. View record in Web of Science®
  4. WOS: 000274446400009

Library Notes

  1. Fiscal Year: FY2009-2010
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