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[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses

  1. Author:
    Yang, D.
    Zhao, Y. L.
    Guo, H.
    Li, Y. N.
    Tewary, P.
    Xing, G. M.
    Hou, W.
    Oppenheim, J. J.
    Zhang, N.

  2. Author Address

    [Yang, De; Guo, Hua; Hou, Wei; Zhang, Ning] Tianjin Med Univ, Res Ctr Basic Med Sci, Canc Inst & Hosp, Key Lab Breast Canc Res,Minist Educ, Tianjin 300060, Peoples R China. [Yang, De; Li, Yana; Tewary, Poonam; Oppenheim, Joost J.] NCI, Basic Res Program, SAIC Frederick Inc,Ctr Canc Res, Lab Mol Immunoregulat,Canc & Inflammat Program, Frederick, MD 21702 USA. [Zhao, Yuliang; Xing, Gengmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China.;Zhang, N, Tianjin Med Univ, Res Ctr Basic Med Sci, Canc Inst & Hosp, Key Lab Breast Canc Res,Minist Educ, Tianjin 300060, Peoples R China.;nzhangchina@yahoo.com
    1. Year: 2010
    2. Date: Feb
  2. Journal: Acs Nano
    1. 4
    2. 2
    3. Pages: 1178-1186
  4. Type of Article: Article
  5. ISSN: 1936-0851
  1. Abstract:

    Dendritic cells play a pivotal role in host immune defense, such as elimination of foreign pathogen and inhibition of tumorigenesis. In this paper, we report that [Gd@C-82(OH)(22)](n) could induce phenotypic maturation of. dendritic cells by stimulating DC production of cytokines including IL-12p70, upregulating DC co-stimulatory (CD80, CD83, and CD86) and MHC (HLA-A,B,C and HLA-DR) molecules, and switching DCs from a CCL5-responsive to a CCL19-responsive phenotype. We found that [Gd@C-82(OH)(22)](n) can induce dendritic cells to become functionally mature as illustrated by their capacity to activate allogeneic T cells. Mice immunized with ovalbumin in the presence of [Gd@C-82(OH)(22)](n) exhibit enhanced ovalbumin-specific Th1-polarized immune response as evidenced by the predominantly increased production of IFN gamma, IL-1 beta, and IL-2. The [Gd@C-82(OH)(22)](n) nanoparticle is a potent activator of dendritic cells and Th1 immune responses. These new findings also provide a rational understanding of the potent anticancer activities of [Gd@C-82(OH)(22)](n) nanoparticles reported previously.

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External Sources

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  2. DOI: 10.1021/nn901478z
  3. View record in Web of Science®
  4. WOS: 000274635800074

Library Notes

  1. Fiscal Year: FY2009-2010
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