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Cancer as a complex developmental disorder - Nineteenth Cornelius P. Rhoads Memorial Award Lecture

  1. Author:
    Dean, M.

  2. Author Address

    Dean M NCI, Frederick Canc Res & Dev Ctr, Human Genet Sect, Lab Genom Divers Bldg 560,Room 21-18 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Human Genet Sect, Lab Genom Divers Frederick, MD 21702 USA
    1. Year: 1998
  2. Journal: Cancer Research
    1. 58
    2. 24
    3. Pages: 5633-5636
  4. Type of Article: Article
  1. Abstract:

    The processes of differentiation and tumorigenesis have been long thought to be connected. The recent identification of Patched, a gene essential for Drosophila embryonic development, as a tumor suppressor has focused attention on the concept that tumorigenesis involves abnormalities of development. In fact, a large number of genes in the signalling pathway of the Patched gene are either tumor suppressors or oncogenes, This supports the concept that growth control is a critical requirement of differentiation, and that aberrant cellular development can contribute to malignancy. Whereas the identification of genes that result in dominantly inherited cancer syndromes has played a vital role in understanding cancer, the vast majority of "sporadic" cancers have properties of a complex genetic disease. Approaches to identify common alleles in cancer-associated genes promise to increase our understanding of the disease and aid the rational design of preventative and therapeutic strategies. [References: 50]

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