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Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela

  1. Author:
    Conesa, A.
    Fernandez-Mestre, M.
    Padron, D.
    Toro, F.
    Silva, N.
    Tassinari, P.
    Blanca, I.
    Martin, M. P.
    Carrington, M.
    Layrisse, Z.

  2. Author Address

    [Fernandez-Mestre, M.; Padron, D.; Layrisse, Z.] Inst Venezolano Invest Cient, Ctr Med Expt Miguel Layrisse, Caracas 1020A, Venezuela. [Conesa, A.; Toro, F.; Silva, N.; Tassinari, P.; Blanca, I.] Cent Univ Venezuela, Fac Med, Inst Inmunol, FOCIS Ctr Excellence, Caracas, Venezuela. [Martin, M. P.; Carrington, M.] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA. [Carrington, M.] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02114 USA. [Carrington, M.] Harvard Univ, Boston, MA 02115 USA.;Fernandez-Mestre, M, Inst Venezolano Invest Cient, Ctr Med Expt Miguel Layrisse, Kilometro 11,Carretera Panamericana,Apdo 21827, Caracas 1020A, Venezuela.;mfernand@ivic.ve
    1. Year: 2010
    2. Date: Jun
  2. Journal: Tissue Antigens
    1. 75
    2. 6
    3. Pages: 724-729
  4. Type of Article: Article
  5. ISSN: 0001-2815
  1. Abstract:

    This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin-like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11-0.29), except for KIR2DS4 (0.68). Forty-five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.

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External Sources

  1. View Full Text
  2. DOI: 10.1111/j.1399-0039.2010.01446.x
  3. View record in Web of Science®
  4. WOS: 000277609000012

Library Notes

  1. Fiscal Year: FY2009-2010
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