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Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users

  1. Author:
    Bar, K. J.
    Li, H.
    Chamberl, A.
    Tremblay, C.
    Routy, J. P.
    Grayson, T.
    Sun, C. X.
    Wang, S. Y.
    Learn, G. H.
    Morgan, C. J.
    Schumacher, J. E.
    Haynes, B. F.
    Keele, B. F.
    Hahn, B. H.
    Shaw, G. M.

  2. Author Address

    [Bar, Katharine J.; Li, Hui; Grayson, Truman; Sun, Chuanxi; Wang, Shuyi; Learn, Gerald H.; Morgan, Charity J.; Schumacher, Joseph E.; Hahn, Beatrice H.; Shaw, George M.] Univ Alabama, Birmingham, AL 35294 USA. [Chamberland, Annie] CHUM, Ctr Rech, Montreal, PQ, Canada. [Tremblay, Cecile] Univ Montreal, Montreal, PQ, Canada. [Routy, Jean Pierre] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ, Canada. [Routy, Jean Pierre] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ, Canada. [Haynes, Barton F.] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Keele, Brandon F.] NCI, SAIC Frederick, Frederick, MD 21701 USA.;Shaw, GM, Univ Alabama, 720 S 20th St,816 KAUL Bldg, Birmingham, AL 35294 USA.;gshaw@uab.edu
    1. Year: 2010
    2. Date: Jun
  2. Journal: Journal of Virology
    1. 84
    2. 12
    3. Pages: 6241-6247
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, a recent study of injection drug users (IDUs) from St. Petersburg, Russia, also found most subjects to be acutely infected by a single virus. Here, we show by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses. Multivariant transmission was more common in IDUs than in heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 to 31.27; P = 0.008). These findings highlight the diversity in HIV-1 infection risks among different IDU cohorts and the challenges faced by vaccines in protecting against this mode of infection.

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External Sources

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  2. DOI: 10.1128/jvi.00077-10
  3. View record in Web of Science®
  4. WOS: 000277733900037

Library Notes

  1. Fiscal Year: FY2009-2010
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