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Characterization of the human ventricular cerebrospinal fluid proteome obtained from hydrocephalic patients

  1. Author:
    Waybright, T.
    Avellino, A. M.
    Ellenbogen, R. G.
    Hollinger, B. J.
    Veenstra, T. D.
    Morrison, R. S.

  2. Author Address

    [Waybright, Timothy; Hollinger, Bradley J.; Veenstra, Timothy D.] NCI, SAIC Frederick Inc, Lab Prote & Analyt Technol, Adv Technol Program, Frederick, MD 21702 USA. [Avellino, Anthony M.; Ellenbogen, Richard G.] Seattle Childrens Hosp, Dept Neurol Surg, Seattle, WA 98105 USA. [Avellino, Anthony M.; Ellenbogen, Richard G.; Morrison, Richard S.] Univ Washington, Sch Med, Dept Neurol Surg, Seattle, WA 98195 USA.;Veenstra, TD, NCI, SAIC Frederick Inc, Lab Prote & Analyt Technol, Adv Technol Program, POB B,Bldg 469,Rm 160, Frederick, MD 21702 USA.;veenstra@ncifcrf.gov yael@u.washington.edu
    1. Year: 2010
    2. Date: Apr
  2. Journal: Journal of Proteomics
    1. 73
    2. 6
    3. Pages: 1156-1162
  4. Type of Article: Proceedings Paper
  5. ISSN: 1874-3919
  1. Abstract:

    The continuing expansion of proteomic technology has been fueled by the potential for discovering novel biomarkers that may be used for the early detection of disease. It has been proposed that human cerebrospinal fluid (CSF), which surrounds and protects the brain and spinal cord from traumatic injury, may be a valuable target for the diagnosis of a variety of conditions such as Alzheimer's disease, traumatic brain injury, amyotrophic lateral sclerosis and Parkinson's disease. The immense complexity of biofluids, however, still requires that considerable development be made in the analytical techniques used so that comprehensive coverage of the proteins present in such samples is achieved. Using a simple separation strategy the protein complement of human ventricular cerebrospinal fluid obtained from patients with hydrocephalus was evaluated. The study resulted in the identification of over 1500 unique proteins that were found within all nine CSF samples that were analyzed. Comparison with the HUPO serum proteome database demonstrated that human ventricular CSF contains a large array of proteins that may be unique to CSF. This analysis greatly increases our knowledge of the protein content of this clinically important biofluid. (C) 2010 Elsevier B.V. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.jprot.2010.02.004
  3. View record in Web of Science®
  4. WOS: 000277763800013

Library Notes

  1. Fiscal Year: FY2009-2010
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