Skip NavigationSkip to Content
Return Return to Search Results

Cd16 Cross-Linking Blocks Rearrangement of the Tcr-Beta Locus and Development of Alpha-Beta T Cells and Induces Development of Nk Cells From Thymic Progenitors

  1. Author:
    Durum, S. K.
    Lee, C. K.
    Geiman, T. M.
    Murphy, W. J.
    Muegge, K.

  2. Author Address

    Durum SK NCI LAB IMMUNOREGULAT DIV BASIC SCI BLDG 560 ROOM 31-71 FREDERICK, MD 21702 USA NCI SCI APPLICAT INT CORP FREDERICK, MD 21702 USA NCI LAB IMMUNOREGULAT DIV BASIC SCI FREDERICK, MD 21702 USA
    1. Year: 1998
  2. Journal: Journal of Immunology
    1. 161
    2. 7
    3. Pages: 3325-3329
  4. Type of Article: Article
  1. Abstract:

    Mouse thymocytes normally develop into T lymphocytes, but the embryonic thymus also contains precursor cells capable of developing into NK cells. Here, we describe conditions that induce pro-T cells to develop into NK cells, CD16 is expressed on thymic pro-T cells. We observed that CD16 cross-linking during culture of embryonic thymic organs suppressed rearrangement of the TCR beta locus (but did not inhibit TCR gamma locus rearrangement). Rearrangement of the TCR beta locus is normally required for development to the CD4(+)CD8(+), and this development was also suppressed by CD16 cross-linking. The ability of CD16 crosslinking to block alpha beta T cell development was not attributable to toxic effects, but rather was accompanied by promotion of development into NK cells, identified based on molecular and functional criteria. These results suggest that common lymphoid precursors can respond to environmental signals to commit to the alpha beta T vs NK developmental pathways. [References: 20]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel