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The Non-Muscle Myosin Heavy Chain 9 Gene (MYH9) Is Not Associated with Lupus Nephritis in African Americans

  1. Author:
    Freedman, B. I.
    Edberg, J. C.
    Comeau, M. E.
    Murea, M.
    Bowden, D. W.
    Divers, J.
    Alarcon, G. S.
    Brown, E. E.
    McGwin, G.
    Kopp, J. B.
    Winkler, C. A.
    Nelson, G. W.
    Illei, G.
    Petri, M.
    Ramsey-Goldman, R.
    Reveille, J. D.
    Vila, L. M.
    Langefeld, C. D.
    Kimberly, R. P.
    Grp, P. S.

  2. Author Address

    [Freedman, Barry I.; Comeau, Mary E.; Murea, Mariana; Bowden, Donald W.; Divers, Jasmin; Langefeld, Carl D.] Wake Forest Univ, Bowman Gray Sch Med, Nephrol Sect, Winston Salem, NC 27157 USA. [Edberg, Jeffrey C.; Alarcon, Graciela S.; Brown, Elizabeth E.; McGwin, Gerald, Jr.; Kimberly, Robert P.] Univ Alabama, Birmingham, AL USA. [Kopp, Jeffrey B.] NIDDK, Kidney Dis Sect, NIH, Bethesda, MD USA. [Winkler, Cheryl A.; Nelson, George W.] NCI, Lab Genom Div, SAIC Frederick, NIH, Frederick, MD 21701 USA. [Illei, Gabor] Natl Inst Dent & Craniofacial Res, Gene Therapy & Therapeut Branch, NIH, Bethesda, MD USA. [Petri, Michelle] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Ramsey-Goldman, Rosalind] Northwestern Univ, Feinstein Sch Med, Chicago, IL 60611 USA. [Reveille, John D.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Vila, Luis M.] Univ Puerto Rico, San Juan, PR 00936 USA.;Freedman, BI, Wake Forest Univ, Bowman Gray Sch Med, Nephrol Sect, Med Ctr Blvd, Winston Salem, NC 27157 USA.;bfreedma@wfubmc.edu
    1. Year: 2010
    2. Date: Jul
  2. Journal: American Journal of Nephrology
    1. 32
    2. 1
    3. Pages: 66-72
  4. Type of Article: Article
  5. ISSN: 0250-8095
  1. Abstract:

    Background: African Americans (AA) disproportionately develop lupus nephritis (LN) relative to European Americans and familial clustering supports causative genes. Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN. Methods: Seven MYH9 single nucleotide polymorphisms (SNPs) and the E1 risk haplotype were tested for association with LN in three cohorts of AA. Results: A preliminary analysis revealed that the MYH9 E1 risk haplotype was associated with ESRD in 25 cases with presumed systemic lupus erythematosus (SLE)-associated ESRD, compared to 735 non-SLE controls (odds ratio 3.1; p = 0.010 recessive). Replication analyses were performed in 583 AA with SLE in the PROFILE cohort (318 with LN; 265 with SLE but without nephropathy) and 60 AA from the NIH (39 with LN; 21 with SLE but without nephropathy). Analysis of the NIH and larger PROFILE cohorts, as well as a combined analysis, did not support this association. Conclusions: These results suggest that AA with ESRD and coincident SLE who were recruited from dialysis clinics more likely have kidney diseases in the MYH9-associated spectrum of focal segmental glomerulosclerosis. PROFILE and NIH participants, recruited from rheumatology practices, demonstrate that MYH9 does not contribute substantially to the development of LN in AA. Copyright (C) 2010 S. Karger AG, Basel

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External Sources

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  2. DOI: 10.1159/000314688
  3. View record in Web of Science®
  4. WOS: 000278684800009

Library Notes

  1. Fiscal Year: FY2009-2010
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