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D-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS

  1. Author:
    Porter, B. O.
    Ouedraogo, G. L.
    Hodge, J. N.
    Smith, M. A.
    Pau, A.
    Roby, G.
    Kwan, R.
    Bishop, R. J.
    Rehm, C.
    Mican, J.
    Sereti, I.

  2. Author Address

    [Porter, Brian O.; Hodge, Jessica N.; Pau, Alice; Roby, Gregg; Rehm, Catherine; Mican, JoAnn; Sereti, Irini] Natl Inst Allergy & Infect Dis NIAD, NIH, Bethesda, MD USA. [Ouedraogo, G. Laissa] NCI, SAIC Frederick Inc, Clin Monitoring Res Program, Frederick, MD 21702 USA. [Bishop, Rachel J.] NEI, NIH, Bethesda, MD USA. [Smith, Margo A.] Washington Hosp Ctr, Washington, DC 20010 USA. [Kwan, Richard] NIH, Ctr Clin, Bethesda, MD 20892 USA.;Sereti, I, NIH, Ctr Clin, Bldg 10,Room 11B07A,10 Ctr Dr, Bethesda, MD 20892 USA.;isereti@niaid.nih.gov
    1. Year: 2010
    2. Date: Jul
  2. Journal: Clinical Immunology
    1. 136
    2. 1
    3. Pages: 42-50
  4. Type of Article: Article
  5. ISSN: 1521-6616
  1. Abstract:

    Biomarkers could be useful in evaluating immune reconstitution inflammatory syndrome (IRIS). A cohort of 45 HIV-1-infected, antiretroviral treatment (ART)-naive patients with baseline CD4 T cell counts <= 100 cells/mu L who were started on ART, suppressed HIV-RNA to <50 copies/mL, and seen every 1-3 months for 1 year were retrospectively evaluated for suspected or confirmed IRIS. D-Dimer, C-reactive protein (CRP), and selected autoantibodies were analyzed at baseline, 1 and 3 months post-ART in cryopreserved plasma. Median differences between cases and controls were compared with Mann Whitney and Fishers exact tests. Sixteen patients (35.6%) developed IRIS (median of 35 days post-ART initiation): unmasking = 8, paradoxical = 7, autoimmune=1. Pre-ART D-dimer and CRP were higher in IRIS cases versus controls (D-dimer: 0.89 mg/L versus 0.66 mg/L, p=0.037; CRP: 0.74 mg/L versus 0.39 mg/L, p=0.022), while D-dimer was higher in unmasking cases at IRIS onset (2.04 mg/L versus 0.36 mg/L, p=0.05). These biomarkers may be useful in identifying patients at risk for IRIS. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.clim.2010.02.010
  3. View record in Web of Science®
  4. WOS: 000278954300005

Library Notes

  1. Fiscal Year: FY2009-2010
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