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Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion

  1. Author:
    Li, P.
    Burke, S.
    Wang, J. X.
    Chen, X. F.
    Ortiz, M.
    Lee, S. C.
    Lu, D.
    Campos, L.
    Goulding, D.
    Ng, B. L.
    Dougan, G.
    Huntly, B.
    Gottgens, B.
    Jenkins, N. A.
    Copeland, N. G.
    Colucci, F.
    Liu, P. T.

  2. Author Address

    [Li, Peng; Burke, Shannon; Wang, Juexuan; Ortiz, Mariaestela; Lee, Song-Choon; Lu, Dong; Campos, Lia; Goulding, David; Ng, Bee Ling; Dougan, Gordon; Liu, Pentao] Wellcome Trust Sanger Inst, Cambridge CB10 1HH, England. [Burke, Shannon; Colucci, Francesco] Babraham Inst, Lab Lymphocyte Signalling & Dev, Cambridge CB22 3AT, England. [Colucci, Francesco] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England. [Chen, Xiongfeng] NCI, SAIC Frederick, Frederick, MD 21701 USA. [Huntly, Brian; Gottgens, Bertie] Cambridge Inst Med Res, Cambridge CB2 0XY, England. [Jenkins, Nancy A.; Copeland, Neal G.] Inst Mol & Cell Biol, Proteos 138673, Singapore.;Liu, PT, Wellcome Trust Sanger Inst, Cambridge CB10 1HH, England.;pl2@sanger.ac.uk
    1. Year: 2010
    2. Date: Jul
  2. Journal: Science
    1. 329
    2. 5987
    3. Pages: 85-89
  4. Type of Article: Article
  5. ISSN: 0036-8075
  1. Abstract:

    T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.

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External Sources

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  2. DOI: 10.1126/science.1188063
  3. View record in Web of Science®
  4. WOS: 000279402700038

Library Notes

  1. Fiscal Year: FY2009-2010
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