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Adaptive control of innate immunity

  1. Author:
    Shanker, A.

  2. Author Address

    [Shanker, Anil] NCI, Expt Immunol Lab, Canc & Inflammat Program, SAIC Frederick,NIH, Frederick, MD 21702 USA. [Shanker, Anil] NCI, Basic Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Shanker, A, NCI, Expt Immunol Lab, Canc & Inflammat Program, SAIC Frederick,NIH, POB B,Bldg 560,Room 31-27, Frederick, MD 21702 USA.;shankera@mail.nih.gov
    1. Year: 2010
    2. Date: Jul
  2. Journal: Immunology Letters
    1. 131
    2. 2
    3. Pages: 107-112
  4. Type of Article: Review
  5. ISSN: 0165-2478
  1. Abstract:

    The mechanisms by which the immune system responds to an infection or disease depend on a complex interplay between the elements of innate and adaptive immunity. While most of the focus so far has been on the innate instruction of the adaptive immune responses, considerable evidence now suggests an equally important adaptive control of the innate immunity. Several studies yield new insights into how the adaptive immunity by initiating an antigen-specific response can compensate, suppress and activate innate responses at the site of tissue antigen. Here we discuss recent advances in our understanding of the adaptive control of immune effector functions in various pathological and physiological conditions. (C) 2010 Elsevier B.V. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.imlet.2010.04.002
  3. View record in Web of Science®
  4. WOS: 000279703800001

Library Notes

  1. Fiscal Year: FY2009-2010
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