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Nitrogen-bound diazeniumdiolated amidines

  1. Author:
    Biswas, D.
    Deschamps, J. R.
    Keefer, L. K.
    Hrabie, J. A.

  2. Author Address

    [Biswas, Debanjan; Keefer, Larry K.] NCI, Chem Sect, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA. [Deschamps, Jeffrey R.] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. [Hrabie, Joseph A.] NCI, Basic Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Biswas, D, NCI, Chem Sect, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA.;biswasd@mail.nih.gov hrabiej@mail.nih.gov
    1. Year: 2010
    2. Date: Aug 21
  2. Journal: Chemical Communications
    1. 46
    2. 31
    3. Pages: 5799-5801
  4. Type of Article: Article
  5. ISSN: 1359-7345
  1. Abstract:

    In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.

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External Sources

  1. View Full Text
  2. DOI: 10.1039/c0cc00849d
  3. View record in Web of Science®
  4. WOS: 000280514500052

Library Notes

  1. Fiscal Year: FY2009-2010
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