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The ARMS/Kidins220 scaffold protein modulates synaptic transmission

  1. Author:
    Arevalo, J. C.
    Wu, S. H.
    Takahashi, T.
    Zhang, H.
    Yu, T.
    Yano, H.
    Milner, T. A.
    Tessarollo, L.
    Ninan, I.
    Arancio, O.
    Chao, M. V.

  2. Author Address

    [Carlos Arevalo, Juan; Wu, Synphen H.; Yano, Hiroko; Ninan, Ipe; Chao, Moses V.] NYU, Sch Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Dept Cell Biol, New York, NY 10016 USA. [Carlos Arevalo, Juan; Wu, Synphen H.; Yano, Hiroko; Ninan, Ipe; Chao, Moses V.] NYU, Sch Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Dept Physiol & Neurosci, New York, NY 10016 USA. [Carlos Arevalo, Juan; Wu, Synphen H.; Yano, Hiroko; Ninan, Ipe; Chao, Moses V.] NYU, Sch Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Dept Psychiat & Neural Sci, New York, NY 10016 USA. [Carlos Arevalo, Juan; Yu, Tao] Univ Salamanca, Inst Neurociencias Castilla & Leon INCyL, Salamanca 37007, Spain. [Takahashi, Takuya] Yokohama City Univ, Dept Physiol, Grad Sch Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan. [Zhang, Hong; Arancio, Ottavio] Columbia Univ, Dept Pathol, Taub Inst, New York, NY 10032 USA. [Milner, Teresa A.] Weill Cornell Med Coll, Dept Neurol & Neurosci, New York, NY 10065 USA. [Milner, Teresa A.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA. [Tessarollo, Lino] NCI, Neural Dev Grp, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA.;Arevalo, JC, NYU, Sch Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Dept Cell Biol, New York, NY 10016 USA.;arevalojc@usal.es Moses.Chao@med.nyu.edu
    1. Year: 2010
    2. Date: Oct
  2. Journal: Molecular and Cellular Neuroscience
    1. 45
    2. 2
    3. Pages: 92-100
  4. Type of Article: Article
  5. ISSN: 1044-7431
  1. Abstract:

    Activity-dependent changes of synaptic connections are facilitated by a variety of scaffold proteins, including PSD-95, Shank, SAP97 and GRIP, which serve to organize ion channels, receptors and enzymatic activities and to coordinate the actin cytoskeleton. The abundance of these scaffold proteins raises questions about the functional specificity of action of each protein. Here we report that basal synaptic transmission is regulated in an unexpected manner by the ankyrin repeat-rich membrane-spanning (ARMS/Kidins220) scaffold protein. In particular, decreases in the levels of ARMS/Kidins220 in vivo led to an increase in basal synaptic transmission in the hippocampus, without affecting paired pulse facilitation. One explanation to account for the effects of ARMS/Kidins220 is an interaction with the AMPA receptor subunit. GluA1, which could be observed after immunoprecipitation. Importantly, shRNA and cell surface biotinylation experiments indicate that ARMS/Kidins220 levels have an impact on GluA1 phosphorylation and localization. Moreover, ARMS/Kidins220 is a negative regulator of AMPAR function, which was confirmed by inward rectification assays. These results provide evidence that modulation of ARMS/Kidins220 levels can regulate basal synaptic strength in a specific manner in hippocampal neurons. (C) 2010 Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.mcn.2010.06.002
  3. View record in Web of Science®
  4. WOS: 000281347300002

Library Notes

  1. Fiscal Year: FY2010-2011
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