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Deficient Expression of Mrna For the Putative Inductive Factor Bone Morphogenetic Protein-7 in Chemically Initiated Rat Nephroblastomas

  1. Author:
    Higinbotham, K. G.
    Karavanova, I. D.
    Diwan, B. A.
    Perantoni, A. O.

  2. Author Address

    Higinbotham KG NCI FREDERICK CANC RES & DEV CTR COMPARAT CARCINOGENESIS LAB BLDG 538 RM 205E FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR SCI APPLICAT INT CORP INTRAMURAL RES SUPPORT PROGRAM FREDERICK, MD USA
    1. Year: 1998
  2. Journal: Molecular Carcinogenesis
    1. 23
    2. 2
    3. Pages: 53-61
  4. Type of Article: Article
  1. Abstract:

    Wilms' tumor, or nephroblastoma, arises from metanephric blastema and caricatures renal organogenesis. An alteration in at least one of the genes involved in control of renal differentiation is therefore a likely event in tumorigenesis, and indeed some of the genes involved in renal development, for example, hepatocyte growth factor (HGF) and its receptor c-met, the transcription factor Wilms' tumor gene (WT1), and transforming growth factor-p family member bone morphogenetic protein (BMP)-7, have also been implicated in various models of tumorigenesis. In a comparison of mRNA expression patterns for these genes in normal rat embryonic or fetal kidney and nephroblastoma, we found that the patterns for HGF met, and VT1 detected by in situ hybridization or ribonuclease protection assay (RPA) in the nephroblastomas were similar to those of normal developing kidney. BMP-7 expression, on the other hand, was lower in most tumors examined both by in situ hybridization and RPA than in normal tissues. This deficiency in a defined inductive factor that has been shown to function in renal tubulogenesis may play a role in tumorigenesis by allowing the accumulation of blastemal populations typical of nephroblastomas. (C) 1998 Wiley-Liss, Inc. [References: 43]

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