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Determinants of Protection among HIV-Exposed Seronegative Persons: An Overview

  1. Author:
    Lederman, M. M.
    Alter, G.
    Daskalakis, D. C.
    Rodriguez, B.
    Sieg, S. F.
    Hardy, G.
    Cho, M.
    Anthony, D.
    Harding, C.
    Weinberg, A.
    Silverman, R. H.
    Douek, D. C.
    Margolis, L.
    Goldstein, D. B.
    Carrington, M.
    Goedert, J. J.

  2. Author Address

    [Lederman, Michael M.; Rodriguez, Benigno; Sieg, Scott F.; Hardy, Gareth; Anthony, Donald; Harding, Clifford] Case Western Reserve Univ, Sch Med, Univ Hosp Case Med Ctr, Ctr AIDS Res, Cleveland, OH 44106 USA. [Weinberg, Aaron] Case Western Reserve Univ, Sch Dent, Cleveland, OH 44106 USA. [Silverman, Robert H.] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44106 USA. [Alter, Galit] Harvard Univ, Massachusetts Gen Hosp, MIT, Ragon Inst, Boston, MA 02115 USA. [Daskalakis, Demetre C.] NYU, Sch Med, Div Infect Dis & Immunol, New York, NY USA. [Cho, Michael] Iowa State Univ, Coll Vet Med, Ames, IA USA. [Douek, Daniel C.] Natl Inst Allergy Immunol & Infect Dis, Human Immunol Sect, Vaccine Res Ctr, Bethesda, MD USA. [Margolis, Leonid] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA. [Goedert, James J.] NCI, Infect & Immunoepidemiol Branch, NIH, Bethesda, MD 20892 USA. [Carrington, Mary] NCI, Expt Immunol Lab, SAIC Frederick, NIH, Frederick, MD 21701 USA. [Goldstein, David B.] Duke Univ, Inst Genome Sci & Policy, Ctr Human Genome Variat, Durham, NC USA.;Lederman, MM, Case Western Reserve Univ, 2061 Cornell Rd, Cleveland, OH 44106 USA.;MXL6@case.edu
    1. Year: 2010
    2. Date: Nov
  2. Journal: Journal of Infectious Diseases
    1. 202
    2. Pages: S333-S338
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    Both clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected. Although in some instances this may represent good fortune, cohorts of uninfected persons have been reported who are considered at high risk for infection. In these cohorts a variety of characteristics have been proposed as mediating protection, but to date only the 32-base pair deletion in the chemokine (C-C motif) receptor 5 gene, which results in complete failure of cell surface expression of this coreceptor, has been associated with high-level protection from HIV infection. With this in mind, there are probably many other factors that may individually or in combination provide some level of protection from acquisition of HIV infection. Because some of these factors are probably incompletely protective or inconsistently active, identifying them with confidence will be difficult. Nonetheless, clarifying the determinants of protection against HIV infection is a high priority that will require careful selection of high-risk uninfected cohorts, who should undergo targeted studies of plausible mediators and broad screening for unexpected determinants of protection.

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External Sources

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  2. DOI: 10.1086/655967
  3. View record in Web of Science®
  4. WOS: 000282369000003

Library Notes

  1. Fiscal Year: FY2010-2011
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