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Low-Dose Mucosal Simian Immunodeficiency Virus Infection Restricts Early Replication Kinetics and Transmitted Virus Variants in Rhesus Monkeys

  1. Author:
    Liu, J. Y.
    Keele, B. F.
    Li, H.
    Keating, S.
    Norris, P. J.
    Carville, A.
    Mansfield, K. G.
    Tomaras, G. D.
    Haynes, B. F.
    Kolodkin-Gal, D.
    Letvin, N. L.
    Hahn, B. H.
    Shaw, G. M.
    Barouch, D. H.

  2. Author Address

    [Liu, Jinyan; Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA. [Kolodkin-Gal, Dror; Letvin, Norman L.] Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02215 USA. [Keele, Brandon F.] NCI, SAIC Frederick, Frederick, MD 21702 USA. [Li, Hui; Hahn, Beatrice H.; Shaw, George M.] Univ Alabama, Birmingham, AL 35294 USA. [Keating, Sheila; Norris, Philip J.] Univ Calif San Francisco, San Francisco, CA 94118 USA. [Keating, Sheila; Norris, Philip J.] Blood Syst Res Inst, San Francisco, CA 94118 USA. [Carville, Angela; Mansfield, Keith G.] Harvard Univ, Sch Med, New England Primate Res Ctr, Southborough, MA 01772 USA. [Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA.;Barouch, DH, Beth Israel Deaconess Med Ctr, Div Vaccine Res, E CLS 1047,330 Brookline Ave, Boston, MA 02215 USA.;dbarouch@bidmc.harvard.edu
    1. Year: 2010
    2. Date: Oct
  2. Journal: Journal of Virology
    1. 84
    2. 19
    3. Pages: 10406-10412
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Defining the earliest virologic events following human immunodeficiency virus type 1 (HIV-1) transmission may be critical for the design of vaccine strategies aimed at blocking acquisition of HIV-1 infection. In particular, the length of the eclipse phase and the number of transmitted virus variants may define the window in which a prophylactic vaccine must act. Here we show that the dose of the virus inoculum affects these key virologic parameters following intrarectal simian immunodeficiency virus (SIV) infection of rhesus monkeys. Low-dose SIV infection resulted in a lengthened eclipse phase, fewer transmitted virus variants, and decreased innate immune activation compared with these parameters in high-dose SIV infection. These data suggest a mechanism by which it may be considerably easier for a vaccine to protect against low-risk HIV-1 transmission than against high-risk HIV-1 transmission. These findings have implications for the design and interpretation of HIV-1 vaccine efficacy studies.

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External Sources

  1. View Full Text
  2. DOI: 10.1128/jvi.01155-10
  3. View record in Web of Science®
  4. WOS: 000282641800071

Library Notes

  1. Fiscal Year: FY2010-2011
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