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Selectively Enhanced Contextual Fear Conditioning in Mice Lacking the Transcriptional Regulator Ccaat/Enhancer Binding Protein Delta

  1. Author:
    Sterneck, E.
    Paylor, R.
    Jacksonlewis, V.
    Libbey, M.
    Przedborski, S.
    Tessarollo, L.
    Crawley, J. N.
    Johnson, P. F.

  2. Author Address

    Johnson PF NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM EUKARYOT TRANSCRIPT REGULAT SECT FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM EUKARYOT TRANSCRIPT REGULAT SECT FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM NEURAL DEV GRP FREDERICK, MD 21702 USA COLUMBIA UNIV DEPT NEUROL NEUROL RES MOVEMENT DISORDERS DIV NEW YORK, NY 10032 USA NIMH SECT BEHAV NEUROPHARMACOL EXPT THERAPEUT BRANCH NIH BETHESDA, MD 20892 USA
    1. Year: 1998
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 95
    2. 18
    3. Pages: 10908-10913
  4. Type of Article: Article
  1. Abstract:

    CCAAT/enhancer binding protein delta (C/EBP delta) is a transcriptional regulator implicated in the hepatic acute phase response and in adipogenic and myeloid cell differentiation. We found that C/EBP delta is widely expressed in the peripheral and central nervous systems, including neurons of the hippocampal formation, indicating a role in neural functions. To examine the role of C/EBP delta in vivo, we generated mice with a targeted deletion of the C/EBP delta gene. This mutation does not interfere with normal embryonic and postnatal development. Performance in a battery of behavioral tests indicates that basic neurological functions are normal. Furthermore, performance in a Morris water maze task suggests that C/EBP delta mutant mice have normal spatial learning. However, in the contextual and auditory-cue-conditioned fear task, C/EBP delta null mice displayed significantly more conditioned freezing to the test context than did wild-type controls, but equivalent conditioning to the auditory cue, These data demonstrate a selectively enhanced contextual fear response in mice carrying a targeted genomic mutation and implicate C/EBP delta in the regulation of a specific type of learning and memory. [References: 50]

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