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HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer

  1. Author:
    Martin, M. P.
    Borecki, I. B.
    Zhang, Z. Y.
    Nguyen, L.
    Ma, D. D.
    Gao, X. J.
    Qi, Y.
    Carrington, M.
    Rader, J. S.

  2. Author Address

    [Martin, Maureen P.; Gao, Xiaojiang; Qi, Ying; Carrington, Mary] NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Zhang, Zhengyan; Nguyen, Loan; Rader, Janet S.] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA. [Carrington, Mary] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02114 USA. [Carrington, Mary] Harvard Univ, Boston, MA 02114 USA. [Borecki, Ingrid B.; Ma, Duanduan; Rader, Janet S.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.;Rader, JS, Med Coll Wisconsin, Dept Obstet & Gynecol, Milwaukee, WI 53226 USA.;jrader@mcw.edu
    1. Year: 2010
    2. Date: Dec
    3. Epub Date: 9/22/2010
  2. Journal: Immunogenetics
    1. 62
    2. 11-12
    3. Pages: 761-765
  4. Type of Article: Article
  5. ISSN: 0093-7711
  1. Abstract:

    Inherited genetic polymorphisms within immune response genes have been shown to associate with risk of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grade 3. Here, we used the transmission/disequilibrium test to detect disease-liability alleles and investigate haplotype transmission of KIR and HLA class I polymorphisms in a large family-based population of women with cervical cancer and their biological parents (359 trios). The effect of distinct human papillomavirus types was also explored. HLA-Cw group 1 (HLA-Cw alleles with asparagine at position 80), which serves as ligand for certain killer immunoglobulin-like receptors (KIR), was significantly overtransmitted in women with ICC (P = 0.04), and particularly in the subgroup of women infected with high risk HPV16 or 18 subtypes (P = 0.008). These data support the involvement of the HLA-C locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR, but functional studies are essential to confirm this hypothesis.

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External Sources

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  2. DOI: 10.1007/s00251-010-0477-5
  3. PMID: 20857097
  4. View record in Web of Science®
  5. WOS: 000284120700006

Library Notes

  1. Fiscal Year: FY2010-2011
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