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Common Data Elements for Traumatic Brain Injury: Recommendations From the Biospecimens and Biomarkers Working Group

  1. Author:
    Manley, G. T.
    Diaz-Arrastia, R.
    Brophy, M.
    Engel, D.
    Goodman, C.
    Gwinn, K.
    Veenstra, T. D.
    Ling, G.
    Ottens, A. K.
    Tortella, F.
    Hayes, R. L.

  2. Author Address

    [Manley, Geoffrey T.] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94110 USA. [Diaz-Arrastia, Ramon] Univ Texas SW Med Sch, Dallas, TX USA. [Brophy, Mary] Dept Vet Affairs Cooperat Studies Program, Boston, MA USA. [Engel, Doortje] Univ Heidelberg Hosp, Heidelberg, Germany. [Goodman, Clay; Gwinn, Katrina] Baylor Coll Med, Houston, TX 77030 USA. [Veenstra, Timothy D.] NCI, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21701 USA. [Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Ottens, Andrew K.] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Alachua, FL USA.;Manley, GT, Univ Calif San Francisco, Dept Neurosurg, 1001 Potrero Ave,Bldg 1,Room 101, San Francisco, CA 94110 USA.;manleyg@neurosurg.ucsf.edu
    1. Year: 2010
    2. Date: Nov
  2. Journal: Archives of Physical Medicine and Rehabilitation
    1. 91
    2. 11
    3. Pages: 1667-1672
  4. Type of Article: Article
  5. ISSN: 0003-9993
  1. Abstract:

    Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.apmr.2010.05.018
  3. View record in Web of Science®
  4. WOS: 000284346400006

Library Notes

  1. Fiscal Year: FY2010-2011
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