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Is Apparent Diffusion Coefficient Associated with Clinical Risk Scores for Prostate Cancers that Are Visible on 3-T MR Images ?

  1. Author:
    Turkbey, B.
    Shah, V. P.
    Pang, Y. X.
    Bernardo, M.
    Xu, S.
    Kruecker, J.
    Locklin, J.
    Baccala, A. A.
    Rastinehad, A. R.
    Merino, M. J.
    Shih, J. H.
    Wood, B. J.
    Pinto, P. A.
    Choyke, P. L.

  2. Author Address

    [Turkbey, Baris; Shah, Vijay P.; Bernardo, Marcelino; Choyke, Peter L.] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA. [Locklin, Julia; Wood, Bradford J.] NCI, Ctr Intervent Oncol, NIH, Bethesda, MD 20892 USA. [Locklin, Julia; Wood, Bradford J.] NCI, Dept Radiol & Imaging Sci, Ctr Clin, NIH, Bethesda, MD 20892 USA. [Baccala, Angelo A., Jr.; Rastinehad, Ardeshir R.; Pinto, Peter A.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA. [Merino, Maria J.] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. [Shih, Joanna H.] NCI, Biometr Res Branch, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA. [Shah, Vijay P.; Bernardo, Marcelino] NCI, SAIC Frederick, Frederick, MD 21701 USA. [Xu, Sheng; Kruecker, Jochen] Philips Res N Amer, New York, NY USA. [Pang, Yuxi] Philips Healthcare, Cleveland, OH USA.;Choyke, PL, NCI, Mol Imaging Program, NIH, 10 Ctr Dr,MSC 1182,Bldg 10,Room B3B69F, Bethesda, MD 20892 USA.;pchoyke@mail.nih.gov
    1. Year: 2011
    2. Date: Feb
  2. Journal: Radiology
    1. 258
    2. 2
    3. Pages: 488-495
  4. Type of Article: Article
  5. ISSN: 0033-8419
  1. Abstract:

    Purpose: To investigate whether apparent diffusion coefficients (ADCs) derived from diffusion-weighted (DW) magnetic resonance (MR) imaging at 3 T correlate with the clinical risk of prostate cancer in patients with tumors that are visible on MR images, with MR imaging/transrectal ultrasonography (US) fusion-guided biopsy as a reference. Materials and Methods: Forty-eight consecutive patients (median age, 60 years; median serum prostate-specific antigen value, 6.3 ng/mL) who underwent DW imaging during 3-T MR imaging with an endorectal coil were included in this retrospective institutional review board-approved study, and informed consent was obtained from each patient. Patients underwent targeted MR imaging/transrectal US fusion-guided prostate biopsy. Mean ADCs of cancerous target tumors were correlated with Gleason and D'Amico clinical risk scores. The true risk group rate and predictive value of the mean ADC for classifying a tumor by its D'Amico clinical risk score was determined by using linear discriminant and receiver operating characteristic analyses. Results: A significant negative correlation was found between mean ADCs of tumors in the peripheral zone and their Gleason scores (P = .003; Spearman rho = -0.60) and D'Amico clinical risk scores (P < .0001; Spearman rho = -0.69). ADC was found to distinguish tumors in the peripheral zone with intermediate to high clinical risk from those with low clinical risk with a correct classification rate of 0.73. Conclusion: There is a significant negative correlation between ADCs and Gleason and D'Amico clinical risk scores. ADCs may therefore be useful in predicting the aggressiveness of prostate cancer. (C)RSNA, 2010 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100667/-/DC1

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External Sources

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  2. DOI: 10.1148/radiol.10100667
  3. View record in Web of Science®
  4. WOS: 000286653700018

Library Notes

  1. Fiscal Year: FY2010-2011
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