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Increased plasma levels of adipokines and inflammatory markers in older women with persistent HPV infection

  1. Author:
    Baker, R.
    Dauner, J. G.
    Rodriguez, A. C.
    Williams, M. C.
    Kemp, T. J.
    Hildesheim, A.
    Pinto, L. A.

  2. Author Address

    [Baker, Rosalyn; Dauner, Joseph G.; Williams, Marcus C.; Kemp, Troy J.; Pinto, Ligia A.] NCI, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Baker, Rosalyn] NIAID, Div Clin Res ICMOB, NIH, Bethesda, MD 20892 USA. [Cecilia Rodriguez, Ana] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica. [Hildesheim, Allan] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;Pinto, LA, Head NCI Frederick SAIC Frederick Inc, HPV Immunol Lab, Bldg 469,Room 205, Ft Detrick, MD 21702 USA.;pintol@mail.nih.gov
    1. Year: 2011
    2. Date: Mar
  2. Journal: Cytokine
    1. 53
    2. 3
    3. Pages: 282-285
  4. Type of Article: Article
  5. ISSN: 1043-4666
  1. Abstract:

    We observed diminished lymphoproliferation to multiple stimuli in older women with persistent cervical human papillomavirus (HPV) infection. Adipokines are a class of inflammatory cytokines that are altered in some persistent infections. The objective was to compare the level of adipokines and inflammatory cytokines in heparinized plasma from women with persistent HPV cervical infection (Cases, N = 50, over-sampled for their weak lymphoproliferation responses) with women with no evidence of persistent HPV cervical infection (Controls, N = 50, over-sampled for their strong lymphoproliferation responses). Plasma samples were analyzed with multiplex assays for adipokines and inflammatory cytokines. Cases had significantly elevated plasma levels of resistin (p < 0.0001) and sFas (p = 0.0038) as compared to controls. Risk of persistent HPV infection increased significantly with increasing levels of resistin and 8Fas. This is the first study to demonstrate elevated levels of resistin and sFas in HPV persistently infected, older women with decreased immune function expanding the understanding of the systemic inflammation and immune alterations in individuals persistently infected with HPV. Further studies within a larger cohort are needed to define the generalities of these findings and any role adipokines have in persistent HPV infection. (c) 2010 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.cyto.2010.11.014
  3. View record in Web of Science®
  4. WOS: 000287840200003

Library Notes

  1. Fiscal Year: FY2010-2011
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