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Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: A pathology working group review and re-evaluation

  1. Author:
    Hard, G. C.
    Bruner, R. H.
    Cohen, S. M.
    Pletcher, J. M.
    Regan, K. S.

  2. Author Address

    [Bruner, Richard H.] Res Pathol Associates LLC, Clemson, SC 29631 USA. [Cohen, Samuel M.] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA. [Pletcher, John M.] Charles River Labs, Frederick, MD 21701 USA. [Regan, Karen S.] Regan Path Tox Serv, Ashland, OH 44805 USA.;Hard, GC, 203 Paku Dr, Tairua 3508, New Zealand.;gordonhard@msn.com
    1. Year: 2011
    2. Date: Apr
  2. Journal: Regulatory Toxicology and Pharmacology
    1. 59
    2. 3
    3. Pages: 430-436
  4. Type of Article: Review
  5. ISSN: 0273-2300
  1. Abstract:

    An independent Pathology Working Group (PWG) re-evaluated the kidney changes in National Toxicology Program (NIP) toxicology/carcinogenicity studies of tert-butyl alcohol (TBA) in F344/N rats to determine possible mode(s) of action underlying renal tubule tumors in male rats at 2-years. In the 13-week study, the PWG confirmed that the normal pattern of round hyaline droplets in proximal convoluted tubules was replaced by angular droplet accumulation, and identified precursors of granular casts in the outer medulla, changes typical of alpha(2u)-globulin (alpha(2u)-g) nephropathy. In the 2-year study, the PWG confirmed the NIP observation of increased renal tubule tumors in treated male groups. Linear papillary mineralization, another hallmark of the alpha(2u)-g pathway was present only in treated male rats. Chronic progressive nephropathy (CPN) was exacerbated in high-dose males and females, with a relationship between advanced grades of CPN and renal tumor occurrence. Hyperplasia of the papilla lining was a component of CPN in both sexes, but there was no pelvic urothelial hyperplasia. High-dose females showed no TBA-related nephrotoxicity. The PWG concluded that both alpha(2u)-g nephropathy and exacerbated CPN modes of action were operative in TBA renal tumorigenicity in male rats, neither of which has relevance for human cancer risk. (C) 2011 Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.yrtph.2011.01.007
  3. View record in Web of Science®
  4. WOS: 000288981500009

Library Notes

  1. Fiscal Year: FY2010-2011
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