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Neurotrophins modulate the expression of chemokine receptors in the brain

  1. Author:
    Avdoshina, V. A. V.
    Becker, J.
    Campbell, L. A.
    Parsadanian, M.
    Mhyre, T.
    Tessarollo, L.
    Mocchetti, I.

  2. Author Address

    [Avdoshina, V Avdoshina, V; Campbell, LA; Parsadanian, M; Mhyre, T; Mocchetti, I] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA [Becker, J; Tessarollo, L] Natl Canc Inst, Ctr Canc Res, Mouse Canc Genet Program, Neural Dev Grp, Frederick, MD USA;Mocchetti, I (reprint author), Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA;moccheti@georgetown.edu
    1. Year: 2011
    2. Date: Feb
  2. Journal: Journal of Neurovirology
    1. 17
    2. 1
    3. Pages: 58-62
  4. Type of Article: Article
  5. ISSN: 1355-0284
  1. Abstract:

    In the central nervous system, chemokines are primarily mediators of inflammatory processes. Their receptors, in particular, CXCR4 and CCR5, serve as co-factors along with CD4 that permit Human immunodeficiency virus-1 (HIV) infection. Moreover, experimental evidence has shown that CXCR4 and CCR5 mediate the neurotoxic effects of the HIV envelope protein gp120, suggesting that these receptors could also promote the neuropathogenesis observed in HIV-positive individuals. Therefore, a better understanding of the molecular mechanisms governing the expression of chemokine receptors in the brain may lead to improved therapies that reduce HIV neurotoxicity. This study presents evidence that the expression of chemokine receptors in the brain is modulated by two neurotrophins in an area-specific manner. This new evidence suggests that the neurotrophins may be an adjunct therapy to reduce HIV-mediated neuronal injury evoked by chemokine receptor activation.

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External Sources

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  2. DOI: 10.1007/s13365-010-0004-3
  3. View record in Web of Science®
  4. WOS: 000289580200007

Library Notes

  1. Fiscal Year: FY2010-2011
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