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Effect of Suppressive Oligodeoxynucleotides on the Development of Inflammation-Induced Papillomas

  1. Author:
    Ikeuchi, H.
    Kinjo, T.
    Klinman, D. M.

  2. Author Address

    [Ikeuchi, H; Kinjo, T; Klinman, DM] NCI, Canc & Inflammat Program, Frederick, MD 21702 USA;Klinman, DM (reprint author), NCI, Canc & Inflammat Program, Bldg 567,Rm 205, Frederick, MD 21702 USA;klinmand@mail.nih.gov
    1. Year: 2011
    2. Date: May
  2. Journal: Cancer Prevention Research
    1. 4
    2. 5
    3. Pages: 752-757
  4. Type of Article: Article
  5. ISSN: 1940-6207
  1. Abstract:

    Inflammation contributes to the development of papillomas and squamous cell carcinomas in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-l3-acetate (TPA) model of skin carcinogenesis. Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs have been shown to block deleterious inflammatory reactions in murine models of autoimmunity, pneumonitis, and shock. This article examines whether treatment with suppressive (Sup) ODN can interfere with DMBA/TPA-induced inflammation, thereby reducing papilloma formation. Results indicate that Sup ODN block TPA-dependent skin hyperplasia, edema, and leukocytic infiltration. Sup ODN also inhibit the upregulation of genes encoding pro-oncogenic chemokines and other markers of inflammation including CXCL2, CCL2, COX-2, and ODC (omithine decarboxylase). Of greatest import, Sup ODN reduce papilloma formation in a dose- and sequence-dependent manner. These findings suggest that Sup ODN may provide a novel means of preventing inflammation and associated oncogenesis. Cancer Prev Res; 4(5); 752-7. (c) 2011 AACR.

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External Sources

  1. View Full Text
  2. DOI: 10.1158/1940-6207.capr-10-0290
  3. View record in Web of Science®
  4. WOS: 000290201100016

Library Notes

  1. Fiscal Year: FY2010-2011
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