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Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes

  1. Author:
    Srinivasula, S.
    Lempicki, R. A.
    Adelsberger, J. W.
    Huang, C. Y.
    Roark, J.
    Lee, P. I.
    Rupert, A.
    Stevens, R.
    Sereti, I.
    Lane, H. C.
    Di Mascio, M.
    Kovacs, J. A.

  2. Author Address

    [Srinivasula, S; Roark, J] NCI, Biostat Res Branch, SAIC Frederick Inc, Frederick, MD 21701 USA [Lempicki, RA; Adelsberger, JW; Rupert, A; Stevens, R] NCI, Appl & Dev Res Directorate, SAIC Frederick Inc, Frederick, MD 21701 USA [Huang, CY; Di Mascio, M] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA [Lee, PI; Sereti, I; Lane, HC] NIAID, Lab Immunoregulat, NIH, Bethesda, MD 20892 USA [Kovacs, JA] NIH Clin Ctr, Crit Care Med Dept, NIH, Bethesda, MD USA;Srinivasula, S (reprint author), 6700A Rockledge Dr,Rm 5227, Bethesda, MD 20817 USA;srinivasulas@mail.nih.gov
    1. Year: 2011
    2. Date: Jul
  2. Journal: Blood
    1. 118
    2. 2
    3. Pages: 262-270
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    We previously showed that HIV infection leads to expansion of a rapidly proliferating pool (s(1)) of CD4 and CD8 T lymphocytes. In the current study, we used in vivo labeling with bromodeoxyuridine to characterize the kinetics of naive, memory, and activated (HLA-DR(+)/CD38(+)) subpopulations of CD4 and CD8 T lymphocytes, and to examine the relationship between kinetic parameters and baseline CD4 counts, HIV viral load, potential markers of microbial translocation, and cytokine levels. Activated cells showed the highest proliferation rates, followed by effector and central memory cells, with naive cells showing the lowest rates, for both CD4 and CD8 T cells. HIV viral load correlated with s(1) of CD4 and CD8 effector memory cells, as well as CD8 naive cells, whereas CD4 cell counts correlated inversely with naive CD4 s(1). Endotoxin levels showed a weak negative association with CD4 but not CD8 s(1). INF-gamma and TNF-alpha were associated with s(1) for CD4 and CD8 cells, respectively. Thus, HIV is the primary driving force behind the activation and proliferation of most subsets of both CD4 and CD8 T lymphocytes, whereas naive CD4 cell proliferation likely represents a homeostatic response. Microbial translocation does not appear to play an important role in this proliferation. (Blood.2011;118(2):262-270)

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External Sources

  1. View Full Text
  2. DOI: 10.1182/blood-2011-02-335174
  3. View record in Web of Science®
  4. WOS: 000292735100010

Library Notes

  1. Fiscal Year: FY2010-2011
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