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14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression

  1. Author:
    Freeman, A. K.
    Morrison, D. K.

  2. Author Address

    [Freeman, AK; Morrison, DK] NCI, Lab Cell & Dev Signaling, Frederick, MD 21702 USA.;Morrison, DK (reprint author), NCI, Lab Cell & Dev Signaling, POB B, Frederick, MD 21702 USA;morrisod@mail.nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Seminars in Cell & Developmental Biology
    1. 22
    2. 7
    3. Pages: 681-687
  4. Type of Article: Review
  5. ISSN: 1084-9521
  1. Abstract:

    The 14-3-3 proteins were the first phosphoserine/phosphothreonine-binding proteins to be discovered, a finding that provided the foundation for their prominent role in cell signaling. 14-3-3 family members interact with a wide spectrum of proteins including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signaling molecules, apoptosis factors, and tumor suppressors. The interaction with 14-3-3 can have a profound effect on a target protein, altering its localization, stability, conformation, phosphorylation state, activity, and/or molecular interactions. Thus, by modulating the function of a diverse array of binding partners, 14-3-3 proteins have become key regulatory components in many vital cellular processes - processes that are crucial for normal growth and development and that often become dysregulated in human cancer. This review will examine the recent advances that further elucidate the role of 14-3-3 proteins in normal growth and cancer signaling with a particular emphasis on the signaling pathways that impact cell proliferation, cell migration, and epithelial-to-mesenchymal transition. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.semcdb.2011.08.009
  3. View record in Web of Science®
  4. WOS: 000296578000004

Library Notes

  1. Fiscal Year: FY2011-2012
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