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Altered distribution of mucosal NK cells during HIV infection

  1. Author:
    Sips, M.
    Sciaranghella, G.
    Diefenbach, T.
    Dugast, A. S.
    Berger, C. T.
    Liu, Q.
    Kwon, D.
    Ghebremichael, M.
    Estes, J. D.
    Carrington, M.
    Martin, J. N.
    Deeks, S. G.
    Hunt, P. W.
    Alter, G.

  2. Author Address

    [Sips, M.; Sciaranghella, G.; Diefenbach, T.; Dugast, A-S; Berger, C. T.; Liu, Q.; Kwon, D.; Ghebremichael, M.; Carrington, M.; Alter, G.] Harvard Univ & Massachusetts Inst Technol, Ragon Inst Massachusetts Gen Hosp, Boston, MA USA. [Estes, J. D.] Frederick Inc, NCI, AIDS & Canc Virus Program, Frederick, MD USA. [Carrington, M.] SAIC Frederick Inc, NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA. [Martin, J. N.; Deeks, S. G.; Hunt, P. W.] Univ Calif San Francisco, Dept Med, Posit Hlth Program, San Francisco, CA USA.;Alter, G (reprint author), Harvard Univ & Massachusetts Inst Technol, Ragon Inst Massachusetts Gen Hosp, Boston, MA USA;galter@partners.org
    1. Year: 2012
    2. Date: Jan
  2. Journal: Mucosal Immunology
    1. 5
    2. 1
    3. Pages: 30-40
  4. Type of Article: Article
  5. ISSN: 1933-0219
  1. Abstract:

    The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s) by which they mediate antiviral activity in the gut is unclear. Here, we show that two distinct subsets of NK cells exist in the gut, one localized to intraepithelial spaces (intraepithelial lymphocytes, IELs) and the other to the lamina propria (LP). The frequency of both subsets of NK cells was reduced in chronic infection, whereas IEL NK cells remained stable in spontaneous controllers with protective killer immunoglobulin-like receptor/human leukocyte antigen genotypes. Both IEL and LP NK cells were significantly expanded in immunological non-responsive patients, who incompletely recovered CD4 + T cells on highly active antiretroviral therapy (HAART). These data suggest that both IEL and LP NK cells may expand in the gut in an effort to compensate for compromised CD4 + T-cell recovery, but that only IEL NK cells may be involved in providing durable control of HIV in the gut.

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External Sources

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  2. DOI: 10.1038/mi.2011.40
  3. View record in Web of Science®
  4. WOS: 000298411100005

Library Notes

  1. Fiscal Year: FY2011-2012
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