Skip NavigationSkip to Content
Return Return to Search Results

Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial

  1. Author:
    Bobe, G.
    Murphy, G.
    Albert, P. S.
    Sansbury, L. B.
    Lanza, E.
    Schatzkin, A.
    Cross, A. J.

  2. Author Address

    [Bobe, Gerd] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA. [Bobe, Gerd] Oregon State Univ, Dept Anim Sci, Corvallis, OR 97331 USA. [Bobe, Gerd; Lanza, Elaine] NCI, Lab Canc Prevent, Ctr Canc Res, NIH,DHHS, Frederick, MD 21701 USA. [Murphy, Gwen; Schatzkin, Arthur; Cross, Amanda J.] NCI, Nutr Epidemiol Branch, DCEG, NIH, Rockville, MD USA. [Albert, Paul S.] NICHHD, Biostat & Bioinformat Branch, NIH, Rockville, MD USA. [Sansbury, Leah B.] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH, Rockville, MD USA.;Bobe, G (reprint author), Oregon State Univ, Linus Pauling Inst, 112 Withycombe Hall, Corvallis, OR 97331 USA;gerd.bobe@oregonstate.edu
    1. Year: 2012
    2. Date: Apr
  2. Journal: International Journal of Cancer
    1. 130
    2. 7
    3. Pages: 1649-1659
  4. Type of Article: Article
  5. ISSN: 0020-7136
  1. Abstract:

    Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex-specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.223.52, p trend = 0.004) but not in men (p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1002/ijc.26184
  3. View record in Web of Science®
  4. WOS: 000299633300019

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel