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Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells

  1. Author:
    Hwang, S. K.
    Minai-Tehrani, A.
    Yu, K. N.
    Chang, S. H.
    Kim, J. E.
    Lee, K. H.
    Park, J.
    Beck, G. R.
    Cho, M. H.

  2. Author Address

    [Hwang, Soon-Kyung; Minai-Tehrani, Arash; Yu, Kyeong-Nam; Chang, Seung-Hee; Kim, Ji-Eun; Cho, Myung-Haing] Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea. [Hwang, Soon-Kyung] NCI, Gene Regulat Sect, Lab Canc Prevent, Ctr Canc Res, Frederick, MD 21702 USA. [Kim, Ji-Eun; Cho, Myung-Haing] Seoul Natl Univ, Dept Nano Fus Technol, Grad Sch Convergence Sci & Technol, Seoul 151742, South Korea. [Cho, Myung-Haing] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 151742, South Korea. [Lee, Kee-Ho] Korea Inst Radiol & Med Sci, Div Radiat Canc Res, Mol Oncol Lab, Seoul 139240, South Korea. [Park, Jongsun] Chungnam Natl Univ, Dept Pharmacol, Res Inst Med Sci, Coll Med,Canc Res Inst,Daejeon Reg Canc Ctr, Taejon 301131, South Korea. [Beck, George R., Jr.] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.;Cho, MH (reprint author), Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea;mchotox@snu.ac.kr
    1. Year: 2012
    2. Date: May
  2. Journal: International Journal of Oncology
    1. 40
    2. 5
    3. Pages: 1515-1524
  4. Type of Article: Article
  5. ISSN: 1019-6439
  1. Abstract:

    Serine/threonine protein kinase 13 (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibits tumor progression by facilitating apoptosis in a mouse lung cancer model. However, the precise mechanism of CTMP-induced apoptosis remains to be elucidated. The present study was performed to examine the role of CTMP in mitochondrial-mediated apoptosis and regulation of mitochondrial function in human lung carcinoma cells. Our results showed that CTMP altered mitochondrial morphology and caused the release of cytochrome c by inhibiting OPA1 expression. Additionally, CTMP facilitated mitochondrial-mediated apoptosis by inhibiting heat-shock protein 27 and preventing cytochrome c interaction with Apaf-1. Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.

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External Sources

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  2. DOI: 10.3892/ijo.2011.1319
  3. View record in Web of Science®
  4. WOS: 000302273400022

Library Notes

  1. Fiscal Year: FY2011-2012
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