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Organization and chromosomal mapping of mouse G(h)/T tissue transglutaminase gene (Tgm2)

  1. Author:
    Nanda, N.
    Iismaa, S. E.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N.
    Graham, R. M.
    Sutrave, P.

  2. Author Address

    Graham RM Victor Chang Cardiac Res Inst, Mol Cardiol Unit 384 Victoria St Darlinghurst NSW 2010 Australia Victor Chang Cardiac Res Inst, Mol Cardiol Unit Darlinghurst NSW 2010 Australia NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Archives of Biochemistry and Biophysics
    1. 366
    2. 1
    3. Pages: 151-156
  4. Type of Article: Article
  1. Abstract:

    The mouse G(h)/tissue transglutaminase gene (Tgm2), coding a dual-function protein that both binds guanosine triphosphate (GTP) and catalyzes the posttranslational modification of proteins by transamidation of glutamine residues, has been cloned. Sequence analysis of Tgm2 and comparison with the TGase sequences of other species allowed correction of several apparent sequencing artifacts in the Tgm2 cDNA. Tgm2 spans approximately 34 kb and has 13 exons and 12 introns. Although the structure of Tgm2 shows similarity to that of other transglutaminase genes, with introns ranging from 921 bp to >5 kb, several introns differ considerably in size from those of the human G(h) gene, TGM2. Tgm2 maps to the distal region of mouse chromosome 2, a region syntenic to human chromo some 20q containing TGM2. Tgm2 is in the vicinity of two uncloned mouse mutations, diminutive (dm) and blind-sterile (bs). Genomic DNA from dm mice was unavailable; however. Southern blot analysis of bs DNA showed no gross rearrangements of Tgm2. (C) 1999 Academic Press. [References: 30]

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