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Positive selection of natural autoreactive B cells

  1. Author:
    Hayakawa, K.
    Asano, M.
    Shinton, S. A.
    Gui, M.
    Allman, D.
    Stewart, C. L.
    Silver, J.
    Hardy, R. R.

  2. Author Address

    Hayakawa K Fox Chase Canc Ctr, Inst Canc Res 7701 Burholme Ave Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Inst Canc Res Philadelphia, PA 19111 USA NCI, Lab Canc & Dev Biol, ABL Basic Res Program, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA Cornell Univ Med Coll, N Shore Univ Hosp, Div Mol Med Manhasset, NY 11030 USA
    1. Year: 1999
  2. Journal: Science
    1. 285
    2. 5424
    3. Pages: 113-116
  4. Type of Article: Article
  1. Abstract:

    Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of seif-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ Line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity. [References: 33]

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