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Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse

  1. Author:
    Su, Hao
    Zhu, Guangzhi
    Djaja P, Ketut Indra
    Lin, Yi
    Gong, Yizhen
    Liu, Xiaoguang
    Li, Jiaquan
    Liu, Zhiming
    Qin, Xiao
    Li, Lequn
    Liu, Tangwei
    Lu, Zili
    Wei, Minyi
    Yan, Lunan
    Winkler, Cheryl
    O'Brien, Stephen J
    Li, Jing
    Xiao, Kaiyin
    Peng, Tao

  2. Author Address

    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China., Experimental Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China., Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China., Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China., Laboratory of Genomic Diversity, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA., Department of Physiology and Pathophysiology, College of Basic Medical Science, Peking University, Health Science Center, Beijing, 100191, China.,
    1. Year: 2017
    2. Date: Aug 15
    3. Epub Date: 2017 May 07
  2. Journal: Oncotarget
    1. 8
    2. 33
    3. Pages: 54402-54415
  4. Type of Article: Article
  5. Article Number: 54402-54415
  1. Abstract:

    In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week before surgery (pTAC group) and 50 did not (non-pTAC group). All patients underwent hepatectomy and postoperative TAC and were followed up to 400 weeks. Samples of liver tissue without HCC and hepatitis (n = 15) served as normal controls. Cellular levels of 8-hydroxy-2 39;-deoxyguanosine (8-OHdG), TP53, and p21waf1/cip1 were measured in both cancer and surrounding tissues using an immunohistochemistry assay. Taken together, our data suggested that preoperative TAC might postpone postoperative HCC relapse within 1 year via suppression of tumor cells by induction of high levels of oxidative stress.

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External Sources

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  2. DOI: 10.18632/oncotarget.17660
  3. PMID: 28903351
  4. PMCID: PMC5589590

Library Notes

  1. Fiscal Year: FY2016-2017
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