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The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine

  1. Author:
    Cortese-Krott, Miriam M.
    Koning, Anne
    Kuhnle, Gunter G. C.
    Nagy, Peter
    Bianco, Christopher L.
    Pasch, Andreas
    Wink, David
    Fukuto, Jon M.
    Jackson, Alan A.
    van Goor, Harry
    Olson, Kenneth R.
    Feelisch, Martin

  2. Author Address

    Heinrich Heine Univ, Med Fac, Dept Cardiol Pneumol & Angiol, Cardiovasc Res Lab, Dusseldorf, Germany.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands.Univ Reading, Dept Food & Nutr Sci, Reading, Berks, England.Natl Inst Oncol, Mol Immunol & Toxicol, Budapest, Hungary.Johns Hopkins Univ, Dept Chem, Charles & 34Th St, Baltimore, MD 21218 USA.Univ Bern, Dept Clin Chem, Bern, Switzerland.Calciscon AG, Bern, Switzerland.NCI, Canc & Inflammat Program, NIH, Frederick, MD 21701 USA.Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USA.Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.Indiana Univ Sch Med South Bend, South Bend, IN USA.Univ Southampton, Southampton Gen Hosp, Fac Med, Clin & Expt Sci, South Acad Block,Level F Mailpoint 810,Tremona Rd, Southampton SO16 6YD, Hants, England.Univ Southampton, Inst Life Sci, South Acad Block,Level F Mailpoint 810,Tremona Rd, Southampton SO16 6YD, Hants, England.
    1. Year: 2017
    2. Date: Oct 1
  2. Journal: Antioxidants & Redox Signaling
  3. MARY ANN LIEBERT, INC,
    1. 27
    2. 10
    3. Pages: 684-712
  5. Type of Article: Article
  6. ISSN: 1523-0864
  1. Abstract:

    Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of antioxidants is ineffective, suggesting that our current understanding of the underlying regulatory processes is incomplete.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1089/ars.2017.7083
  3. PMID: 28398072
  4. PMCID: PMC5576088
  5. View record in Web of Science®
  6. WOS: 000408140000006

Library Notes

  1. Fiscal Year: FY2017-2018
  2. Group/Lab/Department: Cancer and Inflammation Program, Chief = Giorgio Trinchieri (NCI)
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