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HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage

  1. Author:
    Carrington, M.
    Nelson, G. W.
    Martin, M. P.
    Kissner, T.
    Vlahov, D.
    Goedert, J. J.
    Kaslow, R.
    Buchbinder, S.
    Hoots, K.
    O'Brien, S. J.

  2. Author Address

    O'Brien SJ NCI, Lab Genom Divers Frederick, MD 21702 USA NCI, Lab Genom Divers Frederick, MD 21702 USA NCI, Sci Applicat Corp Frederick, Intramural Res Support Program Frederick, MD 21702 USA Johns Hopkins Sch Hyg & Publ Hlth Baltimore, MD 21205 USA NCI, Viral Epidemiol Branch Bethesda, MD 20892 USA Univ Alabama, Multictr Hemophilia Cohort Study Birmingham, AL 35294 USA San Francisco City Clin Cohort San Francisco, CA 94102 USA Univ Texas, Hlth Sci Ctr, Gulf States Hemophilia Ctr Houston, TX 77030 USA
    1. Year: 1999
  2. Journal: Science
    1. 283
    2. 5408
    3. Pages: 1748-1752
  4. Type of Article: Article
  1. Abstract:

    A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human Leukocyte antigen (HLA) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci (A, B, and C) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus-type 1 (HIV-1), whereas individuals who were homozygous for one or more Loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of: AIDS-defining conditions in Caucasians. The extended survival of 28 to 40 percent of HIV1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being Fully heterozygous at HLA class I Loci, to their Lacking the AIDS-associated alleles B*35 and Cw*04, or to both. [References: 66]

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