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beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6

  1. Author:
    Yang, D.
    Chertov, O.
    Bykovskaia, N.
    Chen, Q.
    Buffo, M. J.
    Shogan, J.
    Anderson, M.
    Schroder, J. M.
    Wang, J. M.
    Howard, O. M. Z.
    Oppenheim, J. J.

  2. Author Address

    Oppenheim JJ NCI, Mol Immunoregulat Lab, Div Basic Sci, SAIC Frederick,Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA NCI, Mol Immunoregulat Lab, Div Basic Sci, SAIC Frederick,Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA NCI, Intramural Res Support Program, SAIC Frederick, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA Allegheny Univ Hlth Sci Pittsburgh, PA 15212 USA Magainin Res Inst Plymouth Meeting, PA 19642 USA Univ Kiel, Dept Dermatol D-24105 Kiel Germany
    1. Year: 1999
  2. Journal: Science
    1. 286
    2. 5439
    3. Pages: 525-528
  4. Type of Article: Article
  1. Abstract:

    Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine Ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. [References: 26]

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