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Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

  1. Author:
    Harrison, Oliver J.
    Linehan, Jonathan L.
    Shih, Han-Yu
    Bouladoux, Nicolas
    Han, Seong-Ji
    Smelkinson, Margery
    Sen, Shurjo
    Byrd, Allyson L.
    Enamorado, Michel
    Yao, Chen
    Tamoutounour, Samira
    Van Laethem, Francois
    Hurabielle, Charlotte
    Collins, Nicholas
    Paun, Andrea
    Salcedo, Rosalba
    O'Shea, John J.
    Belkaid, Yasmine

  2. Author Address

    NIAID, Mucosal Immunol Sect, Lab Parasit Dis, 9000 Rockville Pike, Bethesda, MD 20892 USA.NIAMSD, Mol Immunol & Inflammat Branch, Bethesda, MD 20892 USA.NIAID, Microbiome Program, 9000 Rockville Pike, Bethesda, MD 20892 USA.NIAID, Biol Imaging, Res Technol Branch, 9000 Rockville Pike, Bethesda, MD 20892 USA.Leidos Biomedical Res Inc, Basic Sci Program, Canc & Inflammat Program, Frederick Natl Lab Canc Res, Bethesda, MD 20892 USA.NCI, Expt Immunol Branch, Bldg 10, Bethesda, MD 20892 USA.Hop St Louis, INSERM, Unite 976, Paris, France.NIAID, Intracellular Parasite Biol Sect, Lab Parasit Dis, 9000 Rockville Pike, Bethesda, MD 20892 USA.NCI, Canc & Inflammat Program, Bethesda, MD 20892 USA.Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA.Univ Montpellier, Inst Genet Mol Montpellier, CNRS, Montpellier, France.
    1. Year: 2019
    2. Date: Jan 4
    3. Epub Date: 2018 12 06
  2. Journal: Science (New York, N.Y.)
  3. AMER ASSOC ADVANCEMENT SCIENCE,
    1. 363
    2. 6422
    3. Pages: 43-+
  5. Type of Article: Article
  6. Article Number: eaat6280
  7. ISSN: 0036-8075
  1. Abstract:

    Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type 17 program associated with a poised type 2 state. Thus, in the context of injury and exposure to inflammatory mediators such as interleukin-18, these cells rapidly release type 2 cytokines, thereby acquiring contextual functions. Such acquisition of a type 2 effector program promotes tissue repair. Aberrant type 2 responses can also be unleashed in the context of local defects in immunoregulation. Thus, commensal-specific T cells co-opt tissue residency and cell-intrinsic flexibility as a means to promote both local immunity and tissue adaptation to injury.

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External Sources

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  2. DOI: 10.1126/science.aat6280
  3. PMID: 30523076
  4. View record in Web of Science®
  5. WOS: 000455315800053

Library Notes

  1. Fiscal Year: FY2018-2019
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