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E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

  1. Author:
    Phillips, A. C.
    Ernst, M. K.
    Bates, S.
    Rice, N. R.
    Vousden, K. H.

  2. Author Address

    Vousden KH NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program W 7th St Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA SmithKline Beecham Pharmaceut Harlow CM19 5AD Essex England
    1. Year: 1999
  2. Journal: Molecular Cell
    1. 4
    2. 5
    3. Pages: 771-781
  4. Type of Article: Article
  1. Abstract:

    The E2F family of transcription factors plays an essential role in promoting cell cycle progression, and one member of the family, E2F-1, is also capable of inducing apoptosis. We show here that E2F-1 can induce apoptosis by a death receptor-dependent mechanism, by downregulating TRAF2 protein levels and inhibiting activation of antiapoptotic signals including NF-kappa B. In this way, E2F-1 expression can lead to the sensitization of cells to apoptosis by a number of agents independently of p53. Deregulation of E2F-1 activity occurs in the majority of human tumors, and the ability of E2F-1 to inhibit antiapoptotic signaling may contribute to the enhanced sensitivity of transformed cells to chemotherapeutic agents. [References: 59]

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