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Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica

  1. Author:
    Tosun, Fatma
    Beutler,John
    Ransom, Tanya T.
    Miski, Mahmut

  2. Author Address

    Istanbul Medipol Univ, Sch Pharm, Dept Pharmacognosy, TR-34810 Istanbul, Turkey.NCI, Mol Targets Program, CCR, Frederick, MD 21702 USA.Istanbul Univ, Dept Pharmacognosy, Fac Pharm, TR-34116 Istanbul, Turkey.
    1. Year: 2019
    2. Date: Mar 2
    3. Epub Date: 2019 03 23
  2. Journal: Molecules (Basel, Switzerland)
  3. MDPI,
    1. 24
    2. 6
  5. Type of Article: Article
  6. Article Number: 1153
  7. ISSN: 1420-3049
  1. Abstract:

    Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules24061153
  3. PMID: 30909537
  4. PMCID: PMC6471333
  5. View record in Web of Science®
  6. WOS: 000465503800115

Library Notes

  1. Fiscal Year: FY2018-2019
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