Skip NavigationSkip to Content
Return Return to Search Results

Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women

  1. Author:
    Clifford, Gary M.
    Tenet, Vanessa
    Georges, Damien
    Alemany, Laia
    Angel Pavon, Miquel
    Chen, Zigui
    Yeager, Meredith
    Cullen,Michael
    Boland,Joseph
    Bass,Sara
    Steinberg, Mia
    Raine-Bennett, Tina
    Lorey, Thomas
    Wentzensen, Nicolas
    Walker, Joan
    Zuna, Rosemary
    Schiffman, Mark
    Mirabello, Lisa

  2. Author Address

    Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France.Bellvitge Inst Biomed Res, Catalan Inst Oncol, Canc Epidemiol Res Program, Infect & Canc Unit, Barcelona, Spain.CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.CIBER Oncol CIBERONC, Barcelona, Spain.Chinese Univ Hong Kong, Fac Med, Dept Microbiol, Hong Kong, Peoples R China.NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA.Leidos Biomed Res Inc, Canc Genom Res Lab, Frederick, MD USA.Kaiser Permanente Northern Calif, Womens Hlth Res Inst, Div Res, Oakland, CA USA.Kaiser Permanente Northern Calif, Reg Lab, Oakland, CA USA.Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
    1. Year: 2019
    2. Date: JUN
    3. Epub Date: 2019 02 06
  2. Journal: Papillomavirus research (Amsterdam, Netherlands)
  3. ELSEVIER SCIENCE BV,
    1. 7
    2. Pages: 67-74
  5. Type of Article: Article
  6. ISSN: 2405-8521
  1. Abstract:

    Background: Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1-4, B1-4, C1-4, D1-4) which may have differential cervical cancer risk. Methods: A next-generation sequencing assay was used to whole-genome sequence 7116 HPV16-positive cervical samples from well-characterised international epidemiological studies, including 2076 controls, 1878 squamous cell carcinoma (SCC) and 186 adenocarcinoma/adenosquamous cell carcinoma (ADC), and to assign HPV16 sub-lineage. Logistic regression was used to estimate region-stratified country-adjusted odds ratios (OR) and 95%CI. Results: A1 was the most globally widespread sub-lineage, with others showing stronger regional specificity (A3 and A4 for East Asia, B1-4 and C1-4 for Africa, D2 for the Americas, B4, C4 and D4 for North Africa). Increased cancer risks versus A1 were seen for A3, A4 and D (sub)lineages in regions where they were common: A3 in East Asia (OR = 2.2, 95%CI:1.0-4.7); A4 in East Asia (6.6, 3.1-14.1) and North America (3.8, 1.7-8.3); and D in North (6.2, 4.1-9.3) and South/Central America (2.2, 0.8-5.7), where D lineages were also more frequent in ADC than SCC (3.2, 1.5-6.5; 12.1, 5.7-25.6, respectively). Conclusions: HPV16 genetic variation can strongly influence cervical cancer risk. However, burden of cervical cancer attributable to different sub-lineages worldwide is largely driven by historical HPV16 sub-lineage dispersal.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.pvr.2019.02.001
  3. PMID: 30738204
  4. View record in Web of Science®
  5. WOS: 000469800500010

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel